Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

ST Sarvestani; B Cotton; S Fritzlar; TB O'Donnell; JM MacKenzie

Journal article

Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

ST Sarvestani, B Cotton, S Fritzlar, TB O'Donnell, JM MacKenzie

Journal of Interferon and Cytokine Research | MARY ANN LIEBERT, INC | Published : 2016

DOI: 10.1089/jir.2015.0124

Abstract

Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis outbreaks worldwide. In the past decade, research on NoV biology has intensified because of the discovery of murine NoV and subsequently the first cell culture system and small animal model for NoV replication and pathogenesis. In this review, we discuss the current literature on NoV biology, focusing particularly on NoV replication and the interaction between NoV and the host immune response. Understanding the NoV replication cycle and its interaction with cellular processes and innate immune immunity will help develop molecular targets to control human NoV infect..

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University of Melbourne Researchers

Jason Mackenzie Author

Related Projects (1)

NOROVIRUS REPLICATION AND IMMUNE EVASION

Viral gastroenteritis poses an enormous burden in public health and is an emerging problem due to the acute nature of the infection process...

Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

We would like to thank Alexander Wilding for his editorial input in preparation of this article. Work in the authors' laboratory is supported by funding from the National Health and Medical Research Council of Australia (project grant no. 1083139).